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Επιστημονικές Δημοσιεύσεις

Ως ενεργοί επιστήμονες του ελληνικού και διεθνούς χώρου, τα μέλη της Bioncology Care συμμετέχουν ερευνητικά σε ακαδημαικές και κλινικές μελέτες. Στον παρόντα ιστοχώρο, παρουσιάζουμε κάποιες παραπομπές από αυτές.

Επιστημονικά Άρθρα

March 25, 2022

Effect of Osimertinib on CTCs and ctDNA in EGFR Mutant Non-Small Cell Lung Cancer Patients: The Prognostic Relevance of Liquid Biopsy

CONCLUSIONS: The decrease in both CTCs and ctDNA occurring early during osimertinib treatment is predictive…
March 7, 2022

Prophylaxis of cancer-associated venous thromboembolism with low-molecular-weight heparin-tinzaparin: Real world evidence

Thromboprophylaxis, as a preventive measure for cancer-associated thrombosis (CAT), may be beneficial for patients with…
February 24, 2022

Front-Line Bevacizumab plus Chemotherapy with or without Maintenance Therapy for Metastatic Breast Cancer: An Observational Study by the Hellenic Oncology Research Group

Front-line bevacizumab (BEV) in combination with taxanes offers benefit in progression-free survival (PFS) in metastatic…
February 15, 2022

Treatment pathways and associated costs of metastatic colorectal cancer in Greece

CONCLUSIONS: mCRC is a societal challenge for healthcare systems as the treatment is more prolonged…
January 5, 2022

Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma

CONCLUSIONS: The inhibition of two immune checkpoints, LAG-3 and PD-1, provided a greater benefit with…
December 24, 2021

Brain Metastases from Adult Sarcomas: A Retrospective Cohort Study from the Hellenic Group of Sarcomas and Rare Cancers (HGSRC)

Brain metastases are rare events in patients with sarcoma and the available information is relatively…
December 24, 2021

Revisiting the Implications of Positive Germline Testing Results Using Multi-gene Panels in Breast Cancer Patients

CONCLUSION: Germline findings in 92% of individuals are linked to evidence-based treatment information and risk…
November 13, 2021

Vaccine third dose and cancer patients: necessity or luxury?

The current state of the SARS-CoV-2 pandemic is an equilibrium between expanding vaccine coverage on…
November 9, 2021

Early-Onset Colorectal Adenocarcinoma in the IDEA Database: Treatment Adherence, Toxicities, and Outcomes With 3 and 6 Months of Adjuvant Fluoropyrimidine and Oxaliplatin

CONCLUSION: Young age is negatively prognostic in high-risk stage III CRC and associated with significantly…
September 30, 2021

Biopsy and re-biopsy for PD-L1 expression in NSCLC. association between PD-L1 and checkpoint inhibitor efficacy through treatment in NSCLC. A pilot study

CONCLUSION: The findings of this study suggest that the PD-L1-65 index works adequately either concerning…
September 4, 2021

Association of the advanced lung cancer inflammation index (ALI) with immune checkpoint inhibitor efficacy in patients with advanced non-small-cell lung cancer

CONCLUSIONS: The ALI score is a powerful prognostic and predictive biomarker for patients with advanced…
September 3, 2021

Priority of PET-CT vs CT Thorax for EBUS-TBNA 22G vs 19G: Mesothorax Lymphadenopathy

Introduction: Lung lesions and undiagnosed mesothorax lymphadenopathy is an issue that several doctors face in…
August 17, 2021

Effective early diagnosis for NSCLC: an algorithm

INTRODUCTION: Lung cancer still remains undiagnosed for most patients until the disease is inoperable.
June 28, 2021

Personalized Approach to Tissue and Liquid Biopsy after Failure of First-Line EGFR-TKIs: Is There an Issue When Tissue Is Not the Issue? A Case Series

Traditionally, tissue availability from rebiopsy is a prerequisite for adequate sequencing of epidermal growth factor…
June 5, 2021

Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts

Epithelioid hemangioendothelioma (EHE) is an ultra-rare, translocated, vascular sarcoma. EHE clinical behavior is variable, ranging…
April 15, 2021

Comprehensive tumor molecular profile analysis in clinical practice

CONCLUSIONS: Tumor molecular profile analysis using NGS is a first-tier method for a variety of…
April 15, 2021

Intratumoral Treatment with Chemotherapy and Immunotherapy for NSCLC with EBUS-TBNA 19G

Introduction: Immunotherapy is being used for the past five years either as first line or…
January 13, 2021

Duration of Adjuvant Doublet Chemotherapy (3 or 6 months) in Patients With High-Risk Stage II Colorectal Cancer

CONCLUSION: Although noninferiority has not been demonstrated in the overall population, the convenience, reduced toxicity,…
December 4, 2020

Connection between PD-L1 expression and standardized uptake value in NSCLC: an early prognostic treatment combination

Objectives: Lung cancer is still diagnosed at advanced stage and early treatment initiation is needed.…
December 2, 2020

Challenges in sarcoidosis and sarcoid-like reactions associated to immune checkpoint inhibitors: A narrative review apropos of a case

Sarcoidosis and sarcoid-like reactions (SLRs) may develop in association with various malignancies, as well as…
October 9, 2020

Lung cancer biopsies: Comparison between simple 22G, 22G upgraded and 21G needle for EBUS-TBNA

Introduction: Novel technologies are currently used for lung cancer diagnosis. EBUS-TBNA 22G is considered one…
October 5, 2020

Observational Study of Clinical Practice in Patients with Pancreatic Adenocarcinoma in Greece

CONCLUSION: This study described the significant improvement in prognosis of PAC patients receiving palliative chemotherapy…
September 11, 2020

The development of bronchoscopy in China: a national cross-sectional study

Objective: To investigate the development of bronchoscopy in China and compare it with its application…
July 19, 2020

Real-World Data on Thromboprophylaxis in Active Cancer Patients: Where Are We? Are We Getting There?

Background: Cancer patients are at high risk for cancer-associated thrombosis (CAT). CAT is the second…
March 16, 2020

Guidelines for time-to-event end-point definitions in adjuvant randomised trials for patients with localised colon cancer: Results of the DATECAN initiative

CONCLUSION: Standardised definitions of TTE end-points ensure the reproducibility of the end-points between RCTs and…
February 15, 2020

Frequency and predictors of chemotherapy-associated venous thromboembolism: the prospective PREVENT study

CONCLUSIONS: VTE occurrence in this real-world patient cohort was high, reaching almost 20% in certain…
January 2, 2020

Management of Cancer-associated Thrombosis (CAT): Symptomatic or Incidental

CONCLUSION: Incidental thrombosis contributes significantly to CAT burden. Long-term use of LMWH seems to be…
January 2, 2020

Recurrence-free Survival and Safety of Imatinib in Patients With Gastrointestinal Stromal Tumour (GIST) in Greece

CONCLUSION: Adjuvant treatment with imatinib for 3 years in patients with intermediate to high risk…
December 21, 2019

Clinical feasibility of NGS liquid biopsy analysis in NSCLC patients

CONCLUSIONS: This study indicates the feasibility of circulating tumor nucleic acids (ctNA) analysis as a…
September 10, 2019

Second primary melanomas in a cohort of 977 melanoma patients within the first 5 years of monitoring

CONCLUSION: In this cohort, melanoma patients were at 8% risk of an SPM developing within…
July 14, 2019

One in three highly selected Greek patients with breast cancer carries a loss-of-function variant in a cancer susceptibility gene

CONCLUSION: Studying a large and unique cohort of highly selected patients with BC, deriving from…
March 29, 2018

Duration of Adjuvant Chemotherapy for Stage III Colon Cancer

CONCLUSIONS: Among patients with stage III colon cancer receiving adjuvant therapy with FOLFOX or CAPOX,…
January 16, 2018

Nab-paclitaxel as second-line treatment in advanced gastric cancer: a multicenter phase II study of the Hellenic Oncology Research Group

CONCLUSION: Nab-paclitaxel as second-line treatment in locally advanced inoperable or metastatic gastric and gastroesophageal junction…
November 14, 2017

Tumor molecular profiling of NSCLC patients using next generation sequencing

Non‑small cell lung cancer (NSCLC) is the most common type of lung cancer and a…
October 7, 2016

Clinical practice guidelines for the management of metastatic colorectal cancer: a consensus statement of the Hellenic Society of Medical Oncologists (HeSMO)

There is discrepancy and failure to adhere to current international guidelines for the management of…
April 12, 2016

Clinical practice guidelines for the surgical treatment of rectal cancer: a consensus statement of the Hellenic Society of Medical Oncologists (HeSMO)

In rectal cancer management, accurate staging by magnetic resonance imaging, neo-adjuvant treatment with the use…
January 12, 2016

Adjuvant chemotherapy for colon cancer: a consensus statement of the Hellenic and Cypriot Colorectal Cancer Study Group by the HeSMO

Colorectal cancer remains a major cause of cancer mortality in the Western world both in…
June 10, 2015

Gastrointestinal Stromal Tumors (GIST): A Prospective Analysis and an Update on Biomarkers and Current Treatment Concepts

Gastrointestinal stromal tumors (GIST) are the most common sarcomas of the gastrointestinal tract, with transformation…
November 17, 2014

Dose-dense paclitaxel versus docetaxel following FEC as adjuvant chemotherapy in axillary node-positive early breast cancer: a multicenter randomized study of the Hellenic Oncology Research Group (HORG)

Adding a taxane to anthracycline-based adjuvant chemotherapy prolongs survival in node-positive early breast cancer. However,…
November 16, 2014

Docetaxel, gemcitabine and bevacizumab as salvage chemotherapy for HER-2-negative metastatic breast cancer

CONCLUSION: The combination of docetaxel, gemcitabine and bevacizumab has promising activity and manageable toxicity as…
November 6, 2014

Functional aspects of the EGF-induced MAP kinase cascade: a complex self-organizing system approach

The EGF-induced MAP kinase cascade is one of the most important and best characterized networks…
October 3, 2014

Docetaxel and intermittent erlotinib in patients with metastatic Non-Small Cell Lung Cancer; a phase II study from the Hellenic Cooperative Oncology Group

CONCLUSION: Intermittent administration of erlotinib does not appear to improve the clinical outcome of single-agent…
October 9, 2013

Neo-adjuvant chemotherapy in early stage non-small cell lung cancer

Lung cancer treatment has evolved during the last decade from the non-specific cytotoxic drugs to…
October 5, 2013

A multicenter phase I-II study of docetaxel plus epirubicin plus bevacizumab as first-line treatment in women with HER2-negative metastatic breast cancer

CONCLUSIONS: The DEB regimen is a very active but also potentially toxic combination in MBC.…
May 31, 2013

Dose selection trial of metronomic oral vinorelbine monotherapy in patients with metastatic cancer: a hellenic cooperative oncology group clinical translational study

CONCLUSIONS: Considering the antitumor activity and response duration, the negligible toxicity of the highest dose…
April 9, 2013

Postoperative treatment with docetaxel, cisplatin, and capecitabine (DCX) and chemoradiotherapy (CRT) with capecitabine for resected gastric adenocarcinoma

CONCLUSIONS: No further development of this regimen is justified on the basis of poor tolerability…
July 27, 2012

Adjuvant therapy in primary GIST: state-of-the-art

CONCLUSIONS: Key points in systemic adjuvant treatment and clinical management of primary GISTs as well…
January 26, 2012

Detection of methylation in the CpG islands of the p16INK4A, RASSF 1A and methylguanine methyltransferase gene promoters in pancreatic adenocarcinoma

Pancreatic cancer consists of an accumulation of genetic and epigenetic alterations. Recently, aberrant methylation of…
January 4, 2012

Vinorelbine versus paclitaxel for patients with advanced non-small cell lung cancer (NSCLC) and a performance status of 2

CONCLUSION: No significant difference was found in clinical benefit between PS:2 NSCLC patients treated with…
September 23, 2011

A multicenter randomized phase III trial of vinorelbine/gemcitabine doublet versus capecitabine monotherapy in anthracycline- and taxane-pretreated women with metastatic breast cancer

CONCLUSIONS: This trial failed to demonstrate superiority of vinorelbine/gemcitabine doublet over single-agent capecitabine in terms…
October 13, 2010

Screening of the DNA mismatch repair genes MLH1, MSH2 and MSH6 in a Greek cohort of Lynch syndrome suspected families

CONCLUSION: The mutational spectrum of the MMR genes investigated as it has been shaped by…
September 28, 2010

Consensus for EGFR mutation testing in non-small cell lung cancer: results from a European workshop

CONCLUSION: The recommendations of the workshop will help implement EGFR mutation testing in Europe and,…
October 7, 2009

Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw

CONCLUSION: The conclusions of this study validated dental extractions and use of dentures as risk…
November 13, 2008

Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non-small-cell lung cancer patients

CONCLUSIONS: The mRNA expression of BRCA1, RRM1 and RRM2 is potentially a useful tool for…
November 4, 2008

A rare cause of mediastinal mass: Primary liposarcoma

Liposarcoma is the most commonly diagnosed soft tissue sarcoma in adults and occurs predominantly in…
August 14, 2008

Paraneoplastic pemphigus regression after thymoma resection

CONCLUSION: Our case report provides further evidence for the important role of autoantibodies in the…
July 1, 2008

Treatment of non-small cell lung cancer patients with performance status2 (PS2)

Performance status2 (PS2) patients represent a significant proportion of the advanced non-small cell lung cancer…
June 25, 2008

Bisphosphonate-related osteonecrosis of the jaws: a case-control study of risk factors in breast cancer patients

CONCLUSION: The outcome of the present study suggests early referral by oncologists for dental evaluation…
June 11, 2008

Diagnosis of metastatic tumors in cerebrospinal fluid samples using thin-layer cytology

CONCLUSION: CSF cytology is the only examination that verifies the presence of malignancy. Thin monolayer…
May 30, 2008

Docetaxel plus gemcitabine as front-line chemotherapy in elderly patients with lung adenocarcinomas: a multicenter phase II study

CONCLUSIONS: The DG regimen is an active and well-tolerated front-line chemotherapy for elderly patients with…
April 17, 2008

Ribonucleotide reductase subunits M1 and M2 mRNA expression levels and clinical outcome of lung adenocarcinoma patients treated with docetaxel/gemcitabine

Ribonucleotide reductase subunits M1 (RRM1) and M2 (RRM2) are involved in the metabolism of gemcitabine…
March 12, 2008

Distant forearm muscle metastasis from squamous cell lung carcinoma

A case of a 59-year-old man with a distant forearm muscular metastasis due to squamous…
September 4, 2007

Docetaxel versus docetaxel plus gemcitabine as front-line treatment of patients with advanced non-small cell lung cancer: a randomized, multicenter phase III trial

To compare the overall survival (OS) of patients with advanced non-small cell lung (NSCLC) treated…
December 19, 2006

Novel genomic rearrangements in the BRCA1 gene detected in Greek breast/ovarian cancer patients

The identification of genomic rearrangements in breast/ovarian cancer families has widened the mutational spectrum of…
July 5, 2005

Front-line treatment of advanced non-small cell lung cancer with irinotecan and docetaxel: a multicentre phase II study

CONCLUSION: The combination of irinotecan/docetaxel is a relatively active non-platinum-based chemotherapy regimen with manageable toxicity,…
July 28, 2004

Combination of irinotecan (CPT-11) plus oxaliplatin (L-OHP) as first-line treatment in locally advanced or metastatic gastric cancer: a multicentre phase II trial

CONCLUSIONS: The combination of CPT-11/L-OHP is an active regimen as front-line treatment in AGC with…
March 1, 2003

Gastro-intestinal stromal tumors: news and comments

Gastrointestinal stromal tumors (GIST) are rare tumors occuring at all levels of the gastrointestinal tract,…