Επιστημονικές Δημοσιεύσεις

Ως ενεργοί επιστήμονες του ελληνικού και διεθνούς χώρου, τα μέλη της Bioncology Care συμμετέχουν ερευνητικά σε ακαδημαικές και κλινικές μελέτες. Στον παρόντα ιστοχώρο, παρουσιάζουμε κάποιες παραπομπές από αυτές.

Επιστημονικά Άρθρα

Effect of Osimertinib on CTCs and ctDNA in EGFR Mutant Non-Small Cell Lung Cancer Patients: The Prognostic Relevance of Liquid Biopsy
March 25, 2022

Effect of Osimertinib on CTCs and ctDNA in EGFR Mutant Non-Small Cell Lung Cancer Patients: The Prognostic Relevance of Liquid Biopsy

CONCLUSIONS: The decrease in both CTCs and ctDNA occurring early during osimertinib treatment is predictive…
Prophylaxis of cancer-associated venous thromboembolism with low-molecular-weight heparin-tinzaparin: Real world evidence
March 7, 2022

Prophylaxis of cancer-associated venous thromboembolism with low-molecular-weight heparin-tinzaparin: Real world evidence

Thromboprophylaxis, as a preventive measure for cancer-associated thrombosis (CAT), may be beneficial for patients with…
Front-Line Bevacizumab plus Chemotherapy with or without Maintenance Therapy for Metastatic Breast Cancer: An Observational Study by the Hellenic Oncology Research Group
February 24, 2022

Front-Line Bevacizumab plus Chemotherapy with or without Maintenance Therapy for Metastatic Breast Cancer: An Observational Study by the Hellenic Oncology Research Group

Front-line bevacizumab (BEV) in combination with taxanes offers benefit in progression-free survival (PFS) in metastatic…
Treatment pathways and associated costs of metastatic colorectal cancer in Greece
February 15, 2022

Treatment pathways and associated costs of metastatic colorectal cancer in Greece

CONCLUSIONS: mCRC is a societal challenge for healthcare systems as the treatment is more prolonged…
Safety and Efficacy of RAD001 (Everolimus) Administered Upon Relapse During or After Adjuvant Treatment in Post-menopausal Women With Hormone Receptor Positive, HER2/neu Negative Locally Advanced or Metastatic Breast Cancer (CRAD001JGR08 “MELPOMENI” study)
January 30, 2022

Safety and Efficacy of RAD001 (Everolimus) Administered Upon Relapse During or After Adjuvant Treatment in Post-menopausal Women With Hormone Receptor Positive, HER2/neu Negative Locally Advanced or Metastatic Breast Cancer (CRAD001JGR08 “MELPOMENI” study)

CONCLUSION: In the routine care in Greece, EVE demonstrates clinical benefit and a predictable safety…
Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma
January 5, 2022

Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma

CONCLUSIONS: The inhibition of two immune checkpoints, LAG-3 and PD-1, provided a greater benefit with…
Brain Metastases from Adult Sarcomas: A Retrospective Cohort Study from the Hellenic Group of Sarcomas and Rare Cancers (HGSRC)
December 24, 2021

Brain Metastases from Adult Sarcomas: A Retrospective Cohort Study from the Hellenic Group of Sarcomas and Rare Cancers (HGSRC)

Brain metastases are rare events in patients with sarcoma and the available information is relatively…
Revisiting the Implications of Positive Germline Testing Results Using Multi-gene Panels in Breast Cancer Patients
December 24, 2021

Revisiting the Implications of Positive Germline Testing Results Using Multi-gene Panels in Breast Cancer Patients

CONCLUSION: Germline findings in 92% of individuals are linked to evidence-based treatment information and risk…
Vaccine third dose and cancer patients: necessity or luxury?
November 13, 2021

Vaccine third dose and cancer patients: necessity or luxury?

The current state of the SARS-CoV-2 pandemic is an equilibrium between expanding vaccine coverage on…
Early-Onset Colorectal Adenocarcinoma in the IDEA Database: Treatment Adherence, Toxicities, and Outcomes With 3 and 6 Months of Adjuvant Fluoropyrimidine and Oxaliplatin
November 9, 2021

Early-Onset Colorectal Adenocarcinoma in the IDEA Database: Treatment Adherence, Toxicities, and Outcomes With 3 and 6 Months of Adjuvant Fluoropyrimidine and Oxaliplatin

CONCLUSION: Young age is negatively prognostic in high-risk stage III CRC and associated with significantly…
Biopsy and re-biopsy for PD-L1 expression in NSCLC. association between PD-L1 and checkpoint inhibitor efficacy through treatment in NSCLC. A pilot study
September 30, 2021

Biopsy and re-biopsy for PD-L1 expression in NSCLC. association between PD-L1 and checkpoint inhibitor efficacy through treatment in NSCLC. A pilot study

CONCLUSION: The findings of this study suggest that the PD-L1-65 index works adequately either concerning…
Gastrointestinal stromal tumours: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up
September 24, 2021

Gastrointestinal stromal tumours: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up

No abstract
Bone sarcomas: ESMO-EURACAN-GENTURIS-ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up
September 9, 2021

Bone sarcomas: ESMO-EURACAN-GENTURIS-ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up

No abstract
Association of the advanced lung cancer inflammation index (ALI) with immune checkpoint inhibitor efficacy in patients with advanced non-small-cell lung cancer
September 4, 2021

Association of the advanced lung cancer inflammation index (ALI) with immune checkpoint inhibitor efficacy in patients with advanced non-small-cell lung cancer

CONCLUSIONS: The ALI score is a powerful prognostic and predictive biomarker for patients with advanced…
Priority of PET-CT vs CT Thorax for EBUS-TBNA 22G vs 19G: Mesothorax Lymphadenopathy
September 3, 2021

Priority of PET-CT vs CT Thorax for EBUS-TBNA 22G vs 19G: Mesothorax Lymphadenopathy

Introduction: Lung lesions and undiagnosed mesothorax lymphadenopathy is an issue that several doctors face in…
Effective early diagnosis for NSCLC: an algorithm
August 17, 2021

Effective early diagnosis for NSCLC: an algorithm

INTRODUCTION: Lung cancer still remains undiagnosed for most patients until the disease is inoperable.
Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up☆
July 25, 2021

Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up☆

No abstract
Personalized Approach to Tissue and Liquid Biopsy after Failure of First-Line EGFR-TKIs: Is There an Issue When Tissue Is Not the Issue? A Case Series
June 28, 2021

Personalized Approach to Tissue and Liquid Biopsy after Failure of First-Line EGFR-TKIs: Is There an Issue When Tissue Is Not the Issue? A Case Series

Traditionally, tissue availability from rebiopsy is a prerequisite for adequate sequencing of epidermal growth factor…
Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts
June 5, 2021

Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts

Epithelioid hemangioendothelioma (EHE) is an ultra-rare, translocated, vascular sarcoma. EHE clinical behavior is variable, ranging…
Cost-effectiveness of trifluridine/tipiracil as a third-line treatment of metastatic gastric cancer, including adenocarcinoma of the gastrohesophageal junction, among patients previously treated in Greece
April 26, 2021

Cost-effectiveness of trifluridine/tipiracil as a third-line treatment of metastatic gastric cancer, including adenocarcinoma of the gastrohesophageal junction, among patients previously treated in Greece

CONCLUSION: FTD/TPI was estimated to be a cost-effective treatment option for eligible third line mGC…
Comprehensive tumor molecular profile analysis in clinical practice
April 15, 2021

Comprehensive tumor molecular profile analysis in clinical practice

CONCLUSIONS: Tumor molecular profile analysis using NGS is a first-tier method for a variety of…
Intratumoral Treatment with Chemotherapy and Immunotherapy for NSCLC with EBUS-TBNA 19G
April 15, 2021

Intratumoral Treatment with Chemotherapy and Immunotherapy for NSCLC with EBUS-TBNA 19G

Introduction: Immunotherapy is being used for the past five years either as first line or…
Duration of Adjuvant Doublet Chemotherapy (3 or 6 months) in Patients With High-Risk Stage II Colorectal Cancer
January 13, 2021

Duration of Adjuvant Doublet Chemotherapy (3 or 6 months) in Patients With High-Risk Stage II Colorectal Cancer

CONCLUSION: Although noninferiority has not been demonstrated in the overall population, the convenience, reduced toxicity,…
Connection between PD-L1 expression and standardized uptake value in NSCLC: an early prognostic treatment combination
December 4, 2020

Connection between PD-L1 expression and standardized uptake value in NSCLC: an early prognostic treatment combination

Objectives: Lung cancer is still diagnosed at advanced stage and early treatment initiation is needed.…
Effect of duration of adjuvant chemotherapy for patients with stage III colon cancer (IDEA collaboration): final results from a prospective, pooled analysis of six randomised, phase 3 trials
December 3, 2020

Effect of duration of adjuvant chemotherapy for patients with stage III colon cancer (IDEA collaboration): final results from a prospective, pooled analysis of six randomised, phase 3 trials

BACKGROUND: A prospective, pooled analysis of six randomised phase 3 trials was done to investigate…
Challenges in sarcoidosis and sarcoid-like reactions associated to immune checkpoint inhibitors: A narrative review apropos of a case
December 2, 2020

Challenges in sarcoidosis and sarcoid-like reactions associated to immune checkpoint inhibitors: A narrative review apropos of a case

Sarcoidosis and sarcoid-like reactions (SLRs) may develop in association with various malignancies, as well as…
Lung cancer biopsies: Comparison between simple 22G, 22G upgraded and 21G needle for EBUS-TBNA
October 9, 2020

Lung cancer biopsies: Comparison between simple 22G, 22G upgraded and 21G needle for EBUS-TBNA

Introduction: Novel technologies are currently used for lung cancer diagnosis. EBUS-TBNA 22G is considered one…
Observational Study of Clinical Practice in Patients with Pancreatic Adenocarcinoma in Greece
October 5, 2020

Observational Study of Clinical Practice in Patients with Pancreatic Adenocarcinoma in Greece

CONCLUSION: This study described the significant improvement in prognosis of PAC patients receiving palliative chemotherapy…
The development of bronchoscopy in China: a national cross-sectional study
September 11, 2020

The development of bronchoscopy in China: a national cross-sectional study

Objective: To investigate the development of bronchoscopy in China and compare it with its application…
Real-world clinical outcome and toxicity data and economic aspects in patients with advanced breast cancer treated with cyclin-dependent kinase 4/6 (CDK4/6) inhibitors combined with endocrine therapy: the experience of the Hellenic Cooperative Oncology Group
August 21, 2020

Real-world clinical outcome and toxicity data and economic aspects in patients with advanced breast cancer treated with cyclin-dependent kinase 4/6 (CDK4/6) inhibitors combined with endocrine therapy: the experience of the Hellenic Cooperative Oncology Group

CONCLUSIONS: Treatment with CDKi was well tolerated, with a low drug discontinuation rate. Patients who…
Real-World Data on Thromboprophylaxis in Active Cancer Patients: Where Are We? Are We Getting There?
July 19, 2020

Real-World Data on Thromboprophylaxis in Active Cancer Patients: Where Are We? Are We Getting There?

Background: Cancer patients are at high risk for cancer-associated thrombosis (CAT). CAT is the second…
Guidelines for time-to-event end-point definitions in adjuvant randomised trials for patients with localised colon cancer: Results of the DATECAN initiative
March 16, 2020

Guidelines for time-to-event end-point definitions in adjuvant randomised trials for patients with localised colon cancer: Results of the DATECAN initiative

CONCLUSION: Standardised definitions of TTE end-points ensure the reproducibility of the end-points between RCTs and…
Corrigendum to Six versus 12 months of adjuvant trastuzumab in combination with dose-dense chemotherapy for women with HER2-positive breast cancer: a multicenter randomized study by the Hellenic Oncology Research Group (HORG): Annals of Oncology, Volume 26, Issue 7, July 2015, Pages 1333-1340
February 19, 2020

Corrigendum to Six versus 12 months of adjuvant trastuzumab in combination with dose-dense chemotherapy for women with HER2-positive breast cancer: a multicenter randomized study by the Hellenic Oncology Research Group (HORG): Annals of Oncology, Volume 26, Issue 7, July 2015, Pages 1333-1340

No abstract
Frequency and predictors of chemotherapy-associated venous thromboembolism: the prospective PREVENT study
February 15, 2020

Frequency and predictors of chemotherapy-associated venous thromboembolism: the prospective PREVENT study

CONCLUSIONS: VTE occurrence in this real-world patient cohort was high, reaching almost 20% in certain…
Management of Cancer-associated Thrombosis (CAT): Symptomatic or Incidental
January 2, 2020

Management of Cancer-associated Thrombosis (CAT): Symptomatic or Incidental

CONCLUSION: Incidental thrombosis contributes significantly to CAT burden. Long-term use of LMWH seems to be…
Recurrence-free Survival and Safety of Imatinib in Patients With Gastrointestinal Stromal Tumour (GIST) in Greece
January 2, 2020

Recurrence-free Survival and Safety of Imatinib in Patients With Gastrointestinal Stromal Tumour (GIST) in Greece

CONCLUSION: Adjuvant treatment with imatinib for 3 years in patients with intermediate to high risk…
Clinical feasibility of NGS liquid biopsy analysis in NSCLC patients
December 21, 2019

Clinical feasibility of NGS liquid biopsy analysis in NSCLC patients

CONCLUSIONS: This study indicates the feasibility of circulating tumor nucleic acids (ctNA) analysis as a…
Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study
November 5, 2019

Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study

BACKGROUND: Pembrolizumab is active in head and neck squamous cell carcinoma (HNSCC), with programmed cell…
Second primary melanomas in a cohort of 977 melanoma patients within the first 5 years of monitoring
September 10, 2019

Second primary melanomas in a cohort of 977 melanoma patients within the first 5 years of monitoring

CONCLUSION: In this cohort, melanoma patients were at 8% risk of an SPM developing within…
One in three highly selected Greek patients with breast cancer carries a loss-of-function variant in a cancer susceptibility gene
July 14, 2019

One in three highly selected Greek patients with breast cancer carries a loss-of-function variant in a cancer susceptibility gene

CONCLUSION: Studying a large and unique cohort of highly selected patients with BC, deriving from…
Three- versus six-month adjuvant FOLFOX or CAPOX for high-risk stage II and stage III colon cancer patients: the efficacy results of Hellenic Oncology Research Group (HORG) participation to the International Duration Evaluation of Adjuvant Chemotherapy (IDEA) project
June 23, 2019

Three- versus six-month adjuvant FOLFOX or CAPOX for high-risk stage II and stage III colon cancer patients: the efficacy results of Hellenic Oncology Research Group (HORG) participation to the International Duration Evaluation of Adjuvant Chemotherapy (IDEA) project

CONCLUSIONS: The results of the HORG-IDEA study are in line with those of the global…
Panitumumab in combination with modified docetaxel/cisplatin/5-fluorouracil as first-line treatment in gastric and gastroesophageal junction adenocarcinomas: a multicenter phase II study by the Hellenic Oncology Research Group
November 3, 2018

Panitumumab in combination with modified docetaxel/cisplatin/5-fluorouracil as first-line treatment in gastric and gastroesophageal junction adenocarcinomas: a multicenter phase II study by the Hellenic Oncology Research Group

CONCLUSIONS: mDCF/P combination was feasible, though associated with a poor toxicity profile. However, the study…
Soft tissue and visceral sarcomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up
October 5, 2018

Soft tissue and visceral sarcomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

No abstract
Bone sarcomas: ESMO-PaedCan-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up
October 5, 2018

Bone sarcomas: ESMO-PaedCan-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

No abstract
Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up
September 7, 2018

Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

No abstract
Soft tissue and visceral sarcomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up
May 31, 2018

Soft tissue and visceral sarcomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

No abstract
Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up
May 31, 2018

Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

No abstract
Duration of Adjuvant Chemotherapy for Stage III Colon Cancer
March 29, 2018

Duration of Adjuvant Chemotherapy for Stage III Colon Cancer

CONCLUSIONS: Among patients with stage III colon cancer receiving adjuvant therapy with FOLFOX or CAPOX,…
Nab-paclitaxel as second-line treatment in advanced gastric cancer: a multicenter phase II study of the Hellenic Oncology Research Group
January 16, 2018

Nab-paclitaxel as second-line treatment in advanced gastric cancer: a multicenter phase II study of the Hellenic Oncology Research Group

CONCLUSION: Nab-paclitaxel as second-line treatment in locally advanced inoperable or metastatic gastric and gastroesophageal junction…
Tumor molecular profiling of NSCLC patients using next generation sequencing
November 14, 2017

Tumor molecular profiling of NSCLC patients using next generation sequencing

Non‑small cell lung cancer (NSCLC) is the most common type of lung cancer and a…
Sequential vs concurrent epirubicin and docetaxel as adjuvant chemotherapy for high-risk, node-negative, early breast cancer: an interim analysis of a randomised phase III study from the Hellenic Oncology Research Group
June 23, 2017

Sequential vs concurrent epirubicin and docetaxel as adjuvant chemotherapy for high-risk, node-negative, early breast cancer: an interim analysis of a randomised phase III study from the Hellenic Oncology Research Group

CONCLUSIONS: Sequential compared with the concurrent administration of anthracyclines and taxanes is associated with a…
Clinical practice guidelines for the management of metastatic colorectal cancer: a consensus statement of the Hellenic Society of Medical Oncologists (HeSMO)
October 7, 2016

Clinical practice guidelines for the management of metastatic colorectal cancer: a consensus statement of the Hellenic Society of Medical Oncologists (HeSMO)

There is discrepancy and failure to adhere to current international guidelines for the management of…
Dose-dense FEC followed by docetaxel versus docetaxel plus cyclophosphamide as adjuvant chemotherapy in women with HER2-negative, axillary lymph node-positive early breast cancer: a multicenter randomized study by the Hellenic Oncology Research Group (HORG)
August 10, 2016

Dose-dense FEC followed by docetaxel versus docetaxel plus cyclophosphamide as adjuvant chemotherapy in women with HER2-negative, axillary lymph node-positive early breast cancer: a multicenter randomized study by the Hellenic Oncology Research Group (HORG)

CONCLUSIONS: This trial did not clearly demonstrate that TC is non-inferior to dose-dense FEC →…
Cost-Effectiveness Analysis of Panitumumab+Mfolfox over Bevacizumab+Mfolfox as a First-Line Treatment for Metastatic Colorectal Cancer Patients with Wild-Type Ras in Greece
May 21, 2016

Cost-Effectiveness Analysis of Panitumumab+Mfolfox over Bevacizumab+Mfolfox as a First-Line Treatment for Metastatic Colorectal Cancer Patients with Wild-Type Ras in Greece

No abstract
Clinical practice guidelines for the surgical treatment of rectal cancer: a consensus statement of the Hellenic Society of Medical Oncologists (HeSMO)
April 12, 2016

Clinical practice guidelines for the surgical treatment of rectal cancer: a consensus statement of the Hellenic Society of Medical Oncologists (HeSMO)

In rectal cancer management, accurate staging by magnetic resonance imaging, neo-adjuvant treatment with the use…
Adjuvant chemotherapy for colon cancer: a consensus statement of the Hellenic and Cypriot Colorectal Cancer Study Group by the HeSMO
January 12, 2016

Adjuvant chemotherapy for colon cancer: a consensus statement of the Hellenic and Cypriot Colorectal Cancer Study Group by the HeSMO

Colorectal cancer remains a major cause of cancer mortality in the Western world both in…
Clinical practice guidelines for the surgical management of colon cancer: a consensus statement of the Hellenic and Cypriot Colorectal Cancer Study Group by the HeSMO
January 12, 2016

Clinical practice guidelines for the surgical management of colon cancer: a consensus statement of the Hellenic and Cypriot Colorectal Cancer Study Group by the HeSMO

Despite considerable improvement in the management of colon cancer, there is a great deal of…
Gastrointestinal Stromal Tumors (GIST): A Prospective Analysis and an Update on Biomarkers and Current Treatment Concepts
June 10, 2015

Gastrointestinal Stromal Tumors (GIST): A Prospective Analysis and an Update on Biomarkers and Current Treatment Concepts

Gastrointestinal stromal tumors (GIST) are the most common sarcomas of the gastrointestinal tract, with transformation…
Six versus 12 months of adjuvant trastuzumab in combination with dose-dense chemotherapy for women with HER2-positive breast cancer: a multicenter randomized study by the Hellenic Oncology Research Group (HORG)
May 4, 2015

Six versus 12 months of adjuvant trastuzumab in combination with dose-dense chemotherapy for women with HER2-positive breast cancer: a multicenter randomized study by the Hellenic Oncology Research Group (HORG)

CONCLUSIONS: Our study failed to show noninferiority for the 6-month arm. The results further support…
Dose-dense paclitaxel versus docetaxel following FEC as adjuvant chemotherapy in axillary node-positive early breast cancer: a multicenter randomized study of the Hellenic Oncology Research Group (HORG)
November 17, 2014

Dose-dense paclitaxel versus docetaxel following FEC as adjuvant chemotherapy in axillary node-positive early breast cancer: a multicenter randomized study of the Hellenic Oncology Research Group (HORG)

Adding a taxane to anthracycline-based adjuvant chemotherapy prolongs survival in node-positive early breast cancer. However,…
Docetaxel, gemcitabine and bevacizumab as salvage chemotherapy for HER-2-negative metastatic breast cancer
November 16, 2014

Docetaxel, gemcitabine and bevacizumab as salvage chemotherapy for HER-2-negative metastatic breast cancer

CONCLUSION: The combination of docetaxel, gemcitabine and bevacizumab has promising activity and manageable toxicity as…
Functional aspects of the EGF-induced MAP kinase cascade: a complex self-organizing system approach
November 6, 2014

Functional aspects of the EGF-induced MAP kinase cascade: a complex self-organizing system approach

The EGF-induced MAP kinase cascade is one of the most important and best characterized networks…
Docetaxel and intermittent erlotinib in patients with metastatic Non-Small Cell Lung Cancer; a phase II study from the Hellenic Cooperative Oncology Group
October 3, 2014

Docetaxel and intermittent erlotinib in patients with metastatic Non-Small Cell Lung Cancer; a phase II study from the Hellenic Cooperative Oncology Group

CONCLUSION: Intermittent administration of erlotinib does not appear to improve the clinical outcome of single-agent…
Soft tissue and visceral sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
September 12, 2014

Soft tissue and visceral sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

No abstract
Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
September 12, 2014

Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

No abstract
Gastrointestinal stromal tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
September 12, 2014

Gastrointestinal stromal tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

No abstract
Capecitabine in combination with oxaliplatin and bevacizumab (AXELOX) as 1st line treatment for fit and vulnerable elderly patients (aged >70 years) with metastatic colorectal cancer (mCRC): a multicenter phase II study of the Hellenic Oncology Research Group (HORG)
April 24, 2014

Capecitabine in combination with oxaliplatin and bevacizumab (AXELOX) as 1st line treatment for fit and vulnerable elderly patients (aged >70 years) with metastatic colorectal cancer (mCRC): a multicenter phase II study of the Hellenic Oncology Research Group (HORG)

CONCLUSIONS: The combination of capecitabine, oxaliplatin and bevacizumab is an effective and safe combination for…
Neo-adjuvant chemotherapy in early stage non-small cell lung cancer
October 9, 2013

Neo-adjuvant chemotherapy in early stage non-small cell lung cancer

Lung cancer treatment has evolved during the last decade from the non-specific cytotoxic drugs to…
A multicenter phase I-II study of docetaxel plus epirubicin plus bevacizumab as first-line treatment in women with HER2-negative metastatic breast cancer
October 5, 2013

A multicenter phase I-II study of docetaxel plus epirubicin plus bevacizumab as first-line treatment in women with HER2-negative metastatic breast cancer

CONCLUSIONS: The DEB regimen is a very active but also potentially toxic combination in MBC.…
Dose selection trial of metronomic oral vinorelbine monotherapy in patients with metastatic cancer: a hellenic cooperative oncology group clinical translational study
May 31, 2013

Dose selection trial of metronomic oral vinorelbine monotherapy in patients with metastatic cancer: a hellenic cooperative oncology group clinical translational study

CONCLUSIONS: Considering the antitumor activity and response duration, the negligible toxicity of the highest dose…
Postoperative treatment with docetaxel, cisplatin, and capecitabine (DCX) and chemoradiotherapy (CRT) with capecitabine for resected gastric adenocarcinoma
April 9, 2013

Postoperative treatment with docetaxel, cisplatin, and capecitabine (DCX) and chemoradiotherapy (CRT) with capecitabine for resected gastric adenocarcinoma

CONCLUSIONS: No further development of this regimen is justified on the basis of poor tolerability…
Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
September 22, 2012

Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

No abstract
Gastrointestinal stromal tumors: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
September 22, 2012

Gastrointestinal stromal tumors: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

No abstract
Soft tissue and visceral sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
September 22, 2012

Soft tissue and visceral sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

No abstract
Adjuvant therapy in primary GIST: state-of-the-art
July 27, 2012

Adjuvant therapy in primary GIST: state-of-the-art

CONCLUSIONS: Key points in systemic adjuvant treatment and clinical management of primary GISTs as well…
Detection of methylation in the CpG islands of the p16INK4A, RASSF 1A and methylguanine methyltransferase gene promoters in pancreatic adenocarcinoma
January 26, 2012

Detection of methylation in the CpG islands of the p16INK4A, RASSF 1A and methylguanine methyltransferase gene promoters in pancreatic adenocarcinoma

Pancreatic cancer consists of an accumulation of genetic and epigenetic alterations. Recently, aberrant methylation of…
Randomised phase-II trial of CAPIRI (capecitabine, irinotecan) plus bevacizumab vs FOLFIRI (folinic acid, 5-fluorouracil, irinotecan) plus bevacizumab as first-line treatment of patients with unresectable/metastatic colorectal cancer (mCRC)
January 14, 2012

Randomised phase-II trial of CAPIRI (capecitabine, irinotecan) plus bevacizumab vs FOLFIRI (folinic acid, 5-fluorouracil, irinotecan) plus bevacizumab as first-line treatment of patients with unresectable/metastatic colorectal cancer (mCRC)

CONCLUSION: The PFS of FOLFIRI-BEV is not superior to that observed with the CAPIRI-Bev regimen.…
Vinorelbine versus paclitaxel for patients with advanced non-small cell lung cancer (NSCLC) and a performance status of 2
January 4, 2012

Vinorelbine versus paclitaxel for patients with advanced non-small cell lung cancer (NSCLC) and a performance status of 2

CONCLUSION: No significant difference was found in clinical benefit between PS:2 NSCLC patients treated with…
A multicenter randomized phase III trial of vinorelbine/gemcitabine doublet versus capecitabine monotherapy in anthracycline- and taxane-pretreated women with metastatic breast cancer
September 23, 2011

A multicenter randomized phase III trial of vinorelbine/gemcitabine doublet versus capecitabine monotherapy in anthracycline- and taxane-pretreated women with metastatic breast cancer

CONCLUSIONS: This trial failed to demonstrate superiority of vinorelbine/gemcitabine doublet over single-agent capecitabine in terms…
Chemotherapy with gemcitabine, cisplatin, and docetaxel in the treatment for patients with muscle-invasive bladder cancer: a multicenter phase II study of the Hellenic Oncology Research Group (HORG)
July 13, 2011

Chemotherapy with gemcitabine, cisplatin, and docetaxel in the treatment for patients with muscle-invasive bladder cancer: a multicenter phase II study of the Hellenic Oncology Research Group (HORG)

CONCLUSIONS: The GCD combination is an active and well-tolerated regimen in patients with chemotherapy-naive locally…
Screening of the DNA mismatch repair genes MLH1, MSH2 and MSH6 in a Greek cohort of Lynch syndrome suspected families
October 13, 2010

Screening of the DNA mismatch repair genes MLH1, MSH2 and MSH6 in a Greek cohort of Lynch syndrome suspected families

CONCLUSION: The mutational spectrum of the MMR genes investigated as it has been shaped by…
Consensus for EGFR mutation testing in non-small cell lung cancer: results from a European workshop
September 28, 2010

Consensus for EGFR mutation testing in non-small cell lung cancer: results from a European workshop

CONCLUSION: The recommendations of the workshop will help implement EGFR mutation testing in Europe and,…
Soft tissue sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
June 18, 2010

Soft tissue sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

No abstract
Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
June 18, 2010

Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

No abstract
Gastrointestinal stromal tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
June 18, 2010

Gastrointestinal stromal tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

No abstract
Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw
October 7, 2009

Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw

CONCLUSION: The conclusions of this study validated dental extractions and use of dentures as risk…
eComment: The role of lymph node dissection in pulmonary resection for metastases from colorectal cancer
September 24, 2009

eComment: The role of lymph node dissection in pulmonary resection for metastases from colorectal cancer

No abstract
FEC versus sequential docetaxel followed by epirubicin/cyclophosphamide as adjuvant chemotherapy in women with axillary node-positive early breast cancer: a randomized study of the Hellenic Oncology Research Group (HORG)
July 29, 2009

FEC versus sequential docetaxel followed by epirubicin/cyclophosphamide as adjuvant chemotherapy in women with axillary node-positive early breast cancer: a randomized study of the Hellenic Oncology Research Group (HORG)

A randomized multicenter phase III study was conducted to compare the sequential docetaxel followed by…
Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non-small-cell lung cancer patients
November 13, 2008

Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non-small-cell lung cancer patients

CONCLUSIONS: The mRNA expression of BRCA1, RRM1 and RRM2 is potentially a useful tool for…
A rare cause of mediastinal mass: Primary liposarcoma
November 4, 2008

A rare cause of mediastinal mass: Primary liposarcoma

Liposarcoma is the most commonly diagnosed soft tissue sarcoma in adults and occurs predominantly in…
Paraneoplastic pemphigus regression after thymoma resection
August 14, 2008

Paraneoplastic pemphigus regression after thymoma resection

CONCLUSION: Our case report provides further evidence for the important role of autoantibodies in the…
Treatment of non-small cell lung cancer patients with performance status2 (PS2)
July 1, 2008

Treatment of non-small cell lung cancer patients with performance status2 (PS2)

Performance status2 (PS2) patients represent a significant proportion of the advanced non-small cell lung cancer…
Bisphosphonate-related osteonecrosis of the jaws: a case-control study of risk factors in breast cancer patients
June 25, 2008

Bisphosphonate-related osteonecrosis of the jaws: a case-control study of risk factors in breast cancer patients

CONCLUSION: The outcome of the present study suggests early referral by oncologists for dental evaluation…
Diagnosis of metastatic tumors in cerebrospinal fluid samples using thin-layer cytology
June 11, 2008

Diagnosis of metastatic tumors in cerebrospinal fluid samples using thin-layer cytology

CONCLUSION: CSF cytology is the only examination that verifies the presence of malignancy. Thin monolayer…
Docetaxel plus gemcitabine as front-line chemotherapy in elderly patients with lung adenocarcinomas: a multicenter phase II study
May 30, 2008

Docetaxel plus gemcitabine as front-line chemotherapy in elderly patients with lung adenocarcinomas: a multicenter phase II study

CONCLUSIONS: The DG regimen is an active and well-tolerated front-line chemotherapy for elderly patients with…
Gastrointestinal stromal tumors: ESMO clinical recommendations for diagnosis, treatment and follow-up
May 9, 2008

Gastrointestinal stromal tumors: ESMO clinical recommendations for diagnosis, treatment and follow-up

No abstract
Soft tissue sarcomas: ESMO clinical recommendations for diagnosis, treatment and follow-up
May 9, 2008

Soft tissue sarcomas: ESMO clinical recommendations for diagnosis, treatment and follow-up

No abstract
Pooled analysis of elderly patients with non-small cell lung cancer treated with front line docetaxel/gemcitabine regimen: the Hellenic Oncology Research Group experience
May 2, 2008

Pooled analysis of elderly patients with non-small cell lung cancer treated with front line docetaxel/gemcitabine regimen: the Hellenic Oncology Research Group experience

CONCLUSION: The docetaxel/gemcitabine regimen has a comparable efficacy and tolerance in young ( or =…
Ribonucleotide reductase subunits M1 and M2 mRNA expression levels and clinical outcome of lung adenocarcinoma patients treated with docetaxel/gemcitabine
April 17, 2008

Ribonucleotide reductase subunits M1 and M2 mRNA expression levels and clinical outcome of lung adenocarcinoma patients treated with docetaxel/gemcitabine

Ribonucleotide reductase subunits M1 (RRM1) and M2 (RRM2) are involved in the metabolism of gemcitabine…
Gemcitabine plus oxaliplatin (GEMOX) in pretreated patients with advanced ovarian cancer: a multicenter phase II study of the Hellenic Oncology Research Group (HORG)
April 4, 2008

Gemcitabine plus oxaliplatin (GEMOX) in pretreated patients with advanced ovarian cancer: a multicenter phase II study of the Hellenic Oncology Research Group (HORG)

The aim of this study was to evaluate the safety and activity of a gemcitabine-oxaliplatin…
Distant forearm muscle metastasis from squamous cell lung carcinoma
March 12, 2008

Distant forearm muscle metastasis from squamous cell lung carcinoma

A case of a 59-year-old man with a distant forearm muscular metastasis due to squamous…
Paclitaxel and gemcitabine versus carboplatin and gemcitabine in patients with advanced non-small-cell lung cancer. A phase III study of the Hellenic Cooperative Oncology Group
October 17, 2007

Paclitaxel and gemcitabine versus carboplatin and gemcitabine in patients with advanced non-small-cell lung cancer. A phase III study of the Hellenic Cooperative Oncology Group

CONCLUSION: The two regimens are equally active. Myelotoxicity is worse in the CG group whereas…
Docetaxel versus docetaxel plus gemcitabine as front-line treatment of patients with advanced non-small cell lung cancer: a randomized, multicenter phase III trial
September 4, 2007

Docetaxel versus docetaxel plus gemcitabine as front-line treatment of patients with advanced non-small cell lung cancer: a randomized, multicenter phase III trial

To compare the overall survival (OS) of patients with advanced non-small cell lung (NSCLC) treated…
Gemcitabine versus gemcitabine-carboplatin for patients with advanced non-small cell lung cancer and a performance status of 2: a prospective randomized phase II study of the Hellenic Cooperative Oncology Group
April 6, 2007

Gemcitabine versus gemcitabine-carboplatin for patients with advanced non-small cell lung cancer and a performance status of 2: a prospective randomized phase II study of the Hellenic Cooperative Oncology Group

CONCLUSION: No significant difference was found in terms of clinical benefit in patients with NSCLC…
Novel genomic rearrangements in the BRCA1 gene detected in Greek breast/ovarian cancer patients
December 19, 2006

Novel genomic rearrangements in the BRCA1 gene detected in Greek breast/ovarian cancer patients

The identification of genomic rearrangements in breast/ovarian cancer families has widened the mutational spectrum of…
Sequential gemcitabine and cisplatin followed by docetaxel as first-line treatment of advanced urothelial carcinoma: a multicenter phase II study of the Hellenic Oncology Research Group
September 14, 2006

Sequential gemcitabine and cisplatin followed by docetaxel as first-line treatment of advanced urothelial carcinoma: a multicenter phase II study of the Hellenic Oncology Research Group

CONCLUSION: The sequential administration of GP followed by D is active and well tolerated as…
Multicenter phase II study of gemcitabine and oxaliplatin (GEMOX) as second-line chemotherapy in colorectal cancer patients pretreated with 5-fluorouracil plus irinotecan
April 29, 2006

Multicenter phase II study of gemcitabine and oxaliplatin (GEMOX) as second-line chemotherapy in colorectal cancer patients pretreated with 5-fluorouracil plus irinotecan

CONCLUSION: The interesting tumor growth control rate and the favorable toxicity profile of the GEMOX…
Front-line treatment of advanced non-small cell lung cancer with irinotecan and docetaxel: a multicentre phase II study
July 5, 2005

Front-line treatment of advanced non-small cell lung cancer with irinotecan and docetaxel: a multicentre phase II study

CONCLUSION: The combination of irinotecan/docetaxel is a relatively active non-platinum-based chemotherapy regimen with manageable toxicity,…
Combination of irinotecan (CPT-11) plus oxaliplatin (L-OHP) as first-line treatment in locally advanced or metastatic gastric cancer: a multicentre phase II trial
July 28, 2004

Combination of irinotecan (CPT-11) plus oxaliplatin (L-OHP) as first-line treatment in locally advanced or metastatic gastric cancer: a multicentre phase II trial

CONCLUSIONS: The combination of CPT-11/L-OHP is an active regimen as front-line treatment in AGC with…
Irinotecan plus gemcitabine vs irinotecan for the second-line treatment of patients with advanced non-small-cell lung cancer pretreated with docetaxel and cisplatin: a multicentre, randomised, phase II study
July 9, 2004

Irinotecan plus gemcitabine vs irinotecan for the second-line treatment of patients with advanced non-small-cell lung cancer pretreated with docetaxel and cisplatin: a multicentre, randomised, phase II study

To compare irinotecan (CPT-11)+gemcitabine vs CPT-11 alone as second-line treatment for patients with advanced non-small…
Gastro-intestinal stromal tumors: news and comments
March 1, 2003

Gastro-intestinal stromal tumors: news and comments

Gastrointestinal stromal tumors (GIST) are rare tumors occuring at all levels of the gastrointestinal tract,…