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Connection between PD-L1 expression and standardized uptake value in NSCLC: an early prognostic treatment combination

Expert Rev Respir Med. 2021 May;15(5):675-679. doi: 10.1080/17476348.2021.1859373. Epub 2020 Dec 31.

ABSTRACT

Objectives: Lung cancer is still diagnosed at advanced stage and early treatment initiation is needed. Therefore, we need biomarkers or clusters of information that can provide early treatment prognosis.Methods: Biopsies were acquired from 471 patients-lung masses with CT-guided biopsy, convex probe transthorasic biopsy, and EBUS-TBNA convex probe with 18 G needles and 19 G needles.Results: Standardized uptake value (SUV) measurement is associated with female, smoking status, hepatic metastasis, adenocarcinoma and programmed death-ligand 1 (PD-L1). In specific we expect that SUV ≥ 7 is associated with PD-L1 ≥ 50.Conclusions: Lung masses indifferent of size that have SUV ≥ 7 will also have PD-L1 expression ≥ 50. Also, it is likely that these patients will be female with intense smoking habit and hepar or multiple metastasis.

PMID:33275458 | DOI:10.1080/17476348.2021.1859373

Objectives: Lung cancer is still diagnosed at advanced stage and early treatment initiation is needed. Therefore, we need biomarkers or clusters of information that can provide early treatment prognosis.Methods: Biopsies were acquired from 471 patients-lung masses with CT-guided biopsy, convex probe transthorasic biopsy, and EBUS-TBNA convex probe with 18 G needles and 19 G needles.Results: Standardized uptake value (SUV) measurement is associated with female, smoking status, hepatic metastasis,…

Paul Zarogoulidis, Vagelis Christakidis, Dimitris Petridis, Konstantinos Sapalidis, Chriforos Kosmidis, Anastasios Vagionas, Eleni-Isidora Perdikouri, Wolfgang Hohenforst-Schmidt, Haidong Huang, Savvas Petanidis, Kosmas Tsakiridis, Sofia Baka, Konstantinos Romanidis, Bojan Zaric, Tomi Kovacevic, Vladimir Stojsic, Tatjana Sarcev, Daliborka Bursac, Biljana Kukic, Ioannis Boukovinas, Christos Tolis, Chrysanthi Sardeli

2020-12-04

Expert review of respiratory medicine

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